This is a non-exhaustive list of the new features of AmigaOS 4.0 The Final Update since Update #4:

• Exec
  • New memory system.
    • Low Fragmentation, even with long uptimes.
    • Lots of speedups (for example, memory pools are 10 to 20 times faster than before).
    • Named memory.
  • Now uses the MMU to write-protect the .rodata sections of ELF binaries.
• 680x0 emulators
  • Improved compatibility.
  • JIT emulator is between 10 to 50% faster.
• DOS
  • 64-bit support for file sizes.
  • New directory scanning and object examination API.
• Intuition
  • Support for legacy programs requiring a planar screen: normal, HAM6 and HAM8 planar screens are promoted to RTG.
  • Customizable truecolor mouse pointer (in hardware sprite mode on Radeon boards, and in software sprite mode on all boards).
  • Navigation of oversized screens via [Left Amiga] + numeric pad.
• Workbench
  • Support for native 32-bit icons with normal and selected image.
  • Support for loader/saver modules for third-party icon formats.
  • Customizable highlight effect for selected single-image icons.
  • Customizable "left out", "no drop" and "disabled" icon symbols.
  • Removed the remaining 30 character filename length limits.
• Storage controllers support
  • New driver for ITE IT8212 IDE controller.
  • New driver for SCSI 53C8xx-based controllers.
  • Support for IDE ct-flasher hardware added as contribution.
• General
  • Support for alpha channel in IFF ILBM for easy loading, saving, and clipboard copy/paste of truecolor data.
  • No more black background in MultiView when displaying truecolor pictures with an alpha channel.
  • MultiView allows the Workbench screen to be closed and reopened.
  • Smoother appearance for colorwheel.gadget.
  • Customizable images for requester.class requesters.
  • Many parts of OS4 now support the mouse wheel.
• ramdrive.device
  • The classic RAD: no longer survives a soft reboot.
  • The new RESRAD: survives a soft reboot again.
  • The new BOOTRAD: offers booting from a disk image which survives a soft reboot.
• console.device
  • Changing the system default keymap now immediately affects all console windows which dont use a private keymap.
• printer drivers
  • All printer drivers except Printers:File are PPC native.
  • The PostScript printer driver now supports printing pictures in greyscale, B&W and landscape modes. It now uses the current system default charset for text printing to ISO-8859-1 before.
• Printer preferences editor
  • Now PPC native, some new features.
• a1floppy.device
  • New driver for the AmigaOne which has a floppy disk port.
  • Supports booting from floppy disk.
  • Allows limited exchange with Classic Amigas.
• ft2.library
  • Now supports algorithmic font emboldening.
• Fonts
  • The default fonts are now the DejaVu fonts which support more different character sets than the Bitstream Vera fonts.
• USB
  • USB mice and keyboards can now be used to access and navigate EarlyStartup.
  • Keyboard drivers respect user's keyboard key repeat delay and speed.
  • Keyboard drivers can now reset into UBoot.
• Boot menu
  • Early boot menu can be used with only a keyboard.
  • Adjusts its GUI to the screen height which looks better on A1.
• Picasso96 and drivers
  • Radeon Overlay (PIP) support.
  • Extended P96 PIP API (double/triple-buffering possibility allowing perfectly smooth animation).
• AmiGS
  • Localized.
  • Improved printing preferences (page selection, double-sided printing, collation).
• AmiPDF
  • Localized.
  • Improved printing preferences (page selection, double-sided printing, collation).
  • Additional character set support for bookmarks and text copying.
  • More search options.
• Ghostscript
  • Updated to the latest version (8.54).